Equine Protozoal Myeloencephalitis (EPM) is a neurological disease in horses caused by protozoal parasites, primarily Sarcocystis neurona and Neospora hughesi. These parasites infect the central nervous system, leading to inflammation and neurological dysfunction. Clinical signs include asymmetrical muscle atrophy, gait abnormalities, weakness, and incoordination, which can vary in severity depending on the extent of neurological damage.