Systemic Lupus Erythematosus (SLE) in horses is an autoimmune disease causing widespread inflammation affecting skin, joints, and organs.

Systematic Lupus Erthematosus (SLE)

Seek veterinary advice before applying any treatment

Equine systemic lupus erythematosus (SLE) is a polysystemic auto-immune disease with multiple and variable signs in several or many organs or structures. It is associated with the production of autoantibodies that are reactive with nuclear, cytoplasmic, and cell membrane antigens and presents itself as a generalized skin disease, accompanied by antiglobulin-positive anaemia. The disease is remarkable insofar as affected horses may be almost totally hairless.

Symptoms

  • Fur loss
  • Matted
  • Crusted skin
  • Lesions
  • Low appetite
  • Weight loss
  • Dull
  • Lethargy
  • Stiff posture
  • Fever
  • Lameness
  • Swollen lymph nodes
  • Blisters / Sores

Treatment

Glucocorticoids at immunosuppressive dosages are indicated for treatment. Topical glucocorticoids and topical 0.1% tacrolimus are also tried in more localized cases. SLE cases can be more difficult to treat and many horses are euthanized due to a lack of response.

Prevention

Equine systemic lupus erythematosus is not a preventable disease.

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Digital health management offers numerous benefits in modern equine healthcare.

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