Depending upon the effect the virus has on each horse will determine if home or clinical care is warranted. All treatments should be under the direction of a veterinarian.
Treatment includes anti-inflammatories if a fever is present, ensuring the horse receives sufficient fluids, possibly through intravenous treatment if the horse is unable to drink on its own. Oral or intravenous feeding may also be necessary for horses unwilling to eat.
For horses unable to rise slinging is recommended 2 to 3 times per day to aid in circulation and to try to prevent pressure point sores. Head and leg protection is also frequently needed. Many horses will improve within 5 to 7 days of displaying clinical signs, however, about 20-30% can exhibit severe neurological deficits for several weeks.
Some horses sometimes develop other problems because they were weakened by WNV. Joint and tendon infections, sheath infections, pneumonia, and diarrhoea can all occur as secondary events.